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Cloning,Heterologous Expression,and Characterization of the Gene Cluster Required for Gougerotin Biosynthesis
Authors:Guoqing Niu  Lei Li  Junhong Wei  Huarong Tan
Institution:1. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Abstract:
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  • Highlights? The complete gougerotin biosynthetic gene cluster is cloned ? Heterologous production of gougerotin is accomplished in S. coelicolor M1146 ? Biosynthetic pathway is proposed based on bioinformatics, genetic, and chemical analyses ? Preliminary data support an uncommon enzymatic reaction for peptide bond formation
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