Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry |
| |
| Authors: | Pérez-Castro Isabel Caamaño Olga Fernández Franco García Marcos D López Carmen De Clercq Erik |
| |
| Affiliation: | Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain. |
| |
| Abstract: | ![]()
The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2',3'-dideoxy-2'-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2',3'-dideoxy-2',3'-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
