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Activation of CFTR-mediated Cl- Transport by Capsaicinoids in Cell Culture Model |
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| Authors: | ZHAO Xue-liang HOU Ting-ting GE Hong SUN Juan-juan YANG Hong MA Tong-hui Membrane Channel Research Laboratory Northeast Normal University Changchun P R China Liaoning Provincial Key Laboratory of Biotechnology Drug Discovery School of Life Sciences Liaoning Normal University Dalian |
| Institution: | [1]Membrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, P. R. China [2]Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, School of Life Sciences, Liaoning Normal University, Dalian 116029, P. R. China |
| Abstract: | Previous studies reported that capsaicin potentiates F508 mutant cystic fibrosis transmembrane conductance regulator(CFTR) channel gating defect by transfected cell-based assays. It has been postulated that orally ingested capsaicin may conceptually be used to develop a therapeutic strategy to treat gastrointestinal disorders in CF patients. We tried to reproduce and extend those pre-clinical data of previous studies. Cell-based fluorescence functional measurements in Fischer thyroid epithelial cells(FRT) e... |
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