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Intra-arterial application of magnetic nanoparticles for targeted thrombolytic therapy: A rat embolic model |
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| Authors: | Yunn-Hwa Ma Ya-Wun Hsu Yeu-Jhy Chang Mu-Yi Hua Jyh-Ping Chen Tony Wu |
| Institution: | 1. Department of Physiology and Pharmacology, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan;2. Department of Neurology, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan;3. Department of Chemical and Material Engineering, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan |
| Abstract: | Targeted delivery of thrombolytic drug to the site of emboli exhibits potential to greatly reduce hemorrhagic side effect. A rat embolic model with an easy access of a magnet was established for study of the efficacy of magnetic drug targeting. In anesthetized rats, a whole blood clot produced in vitro was injected from the right iliac artery and lodged in the left iliac artery. Intra-arterial infusion of recombinant tissue plasminogen activator (rt-PA) thereafter significantly reversed the iliac flow within 15 min. Placement of an NdFeB magnet above the left iliac artery caused magnetic nanoparticle retention against hemodynamic dragging force in the presence and absence of the clot. Our results suggest the feasibility of this rat embolic model for the study of magnetic targeted delivery of thrombolytic drugs. |
| Keywords: | Magnetic nanoparticle Targeted drug delivery Thrombolysis Tissue plasminogen activator Nanomedicine Thromboembolic disease |
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