Organocatalytic highly enantioselective synthesis of secondary alpha-hydroxyphosphonates |
| |
| Authors: | Dodda Rajasekhar Zhao Cong-Gui |
| |
| Institution: | Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249-0698, USA. |
| |
| Abstract: | reaction: see text] The first organocatalytic cross aldol reaction of ketones and diethyl formylphosphonate hydrate has been realized by using readily available l-prolinamide as the catalyst. Secondary alpha-hydroxyphosphonates have been synthesized in high enantioselective (up to >99% ee) and good diastereoselectivity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
