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l-Cysteine-functionalized magnetic nanoparticles (LCMNP): as a magnetic reusable organocatalyst for one-pot synthesis of 9-(1H-indol-3-yl) xanthen-4-(9H)-ones
Authors:Maryam Nourisefat  Farhad Panahi  Marzieh Nabipour  Sahar Heidari  Ali Khalafi-Nezhad
Affiliation:1.Department of Chemistry, College of Sciences,Shiraz University,Shiraz,Iran
Abstract:
l-Cysteine-functionalized magnetic nanoparticles (LCMNP) were introduced as an efficient and magnetically separable organocatalyst for the synthesis of 9-(1H-indol-3-yl) xanthen-4-(9H)-one derivatives. This class of compounds was synthesized via a one-pot three-component coupling reaction of 2-hydroxybenzaldehyde, dimedone, and indole in the presence of catalytic amount of LCMNP under mild and green conditions. High yields, short reaction time, easy workup, using environmental friendly conditions, and magnetic reusable catalyst are the advantages of this synthetic methodology. The LCMNP catalyst was reusable in this reaction at least for 6 times without significant decreasing in its catalytic activity.
Keywords:
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