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Amidines: synthesis from o-alkenylanilines and cyclization in polyphosphoric acid |
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| Authors: | Gataullin R R Afon'kin I S Abdrakhmanov I B Tolstikov G A |
| Institution: | (1) Institute of Organic Chemistry, Ufa Research Center of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054 Ufa, Russian Federation |
| Abstract: | Condensation of 2-(E)-pent-3-en-2-yl]-4-, 2-(E)-pent-2-en-2-yl]-4-, or 2-(cyclopent-1-enyl)-6-methylaniline with 1-chloro-1-(N-methylimino)- or 1-chloro-1-(N-phenylimino)ethane affords the corresponding amidines. Cyclization of the N-methylimino derivatives in polyphosphoric acid gives 3,4-dihydroquinazolines in high yields. |
| Keywords: | 2-(alk-2-enyl)anilines 2-(alk-1-enyl)anilines amidines intramolecular cyclization 3 4-dihydroquinazolines |
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