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Highly sensitive room-temperature method of non-invasive in vivo detection of magnetic nanoparticles |
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| Authors: | Maxim P. Nikitin Petr M. Vetoshko Petr I. Nikitin |
| Affiliation: | a Department of Molecular & Biological Physics, Moscow Institute of Physics & Technology, Dolgoprudny, 9 Institutskii per., Moscow Region 117303, Russia b Institute of Radioengineering and Electronics, Russian Academy of Sciences, 11 Mokhovaya Street, Moscow 103907, Russia c N.N. Blokhin SE Russian Cancer Research Center RAMS, Moscow 115478, Russia d Natural Science Center, A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, 38 Vavilov Street, Moscow 119991, Russia |
| Abstract: | Methods of non-invasive in vivo quantification of magnetic nanoparticles (MP) have been proposed and realized. The methods are based on non-linear MP magnetization at two frequencies and measuring the response at combinatorial frequencies. The first method is developed for real-time study of MP dynamics and their clearance from the blood system of animals. High sensitivity of 3 ng of Fe3O4 in 0.1 ml was achieved for MP detection in mice tail veins. The second technique is proposed for MP detection inside animal tissues by an external probe. The proposed methods could essentially widen capabilities of biomedical research which involves magnetic nanoparticles. |
| Keywords: | Magnetic and superparamagnetic nanoparticles Non-invasive in vivo detection Non-linear magnetic materials Detection at combinatorial frequencies Magnetic drug delivery Hyperthermia Magnetic immunoassay |
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