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Stereoselective catalytic tishchenko reduction of β-hydroxyketones using scandium triflate |
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| Authors: | Kevin M. Gillespie Ian J. Munslow Peter Scott |
| Affiliation: | aDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, UK |
| Abstract: | A number of aliphatic and aromatic β-hydroxyketones were reduced to 1,3-diol monoesters by aldehydes in the presence of a catalytic amount of scandium triflate. Chiral substrates were reduced with high 1,3-anti diastereoselectivity. |
| Keywords: | scandium scandium compounds reduction aldols diastereoselection |
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