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A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-Toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran |
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| Authors: | Lance J Twyman David Allsop |
| Institution: | aSchool of Physics and Chemistry Lancaster University, Lancaster, LA1 4YQ, UK bDepartment of Biological Sciences, Lancaster University, Lancaster, LA1 4YQ, UK |
| Abstract: | A short and convenient synthesis of 3-p-toluoyl-2-4′-(3-diethylaminopropoxy)-phenyl]-benzofuran, an inhibitor of the aggregation of β-amyloid, which is thought to be the underlying cause of Alzheimer's disease, is described. |
| Keywords: | Benzofurans heterocyclic intramolecular Wittig reaction β-amyloid Alzheimer's disease |
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