| 稀土槲皮素配合物的合成、表征及抗肿瘤活性 |
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| 引用本文： | 丁冶春,夏侯国论,范小娜,王恩军,刘霞.稀土槲皮素配合物的合成、表征及抗肿瘤活性[J].光谱实验室,2011,28(4):1680-1683. |
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| 作者姓名： | 丁冶春 夏侯国论 范小娜 王恩军 刘霞 |
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| 作者单位： | (赣南医学院药学院化学教研室 江西省赣州市章贡区医学院路1号341000 |
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| 基金项目： | 江西省2007年自然科学基金 |
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| 摘 要： | 合成了稀土离子镨、铽的槲皮素配合物,通过元素分析、质谱、摩尔电导、红外光谱、紫外光谱确定了配合物的组成和结构。结果表明,配合物的组成分别为PrC15H8O7Cl10.6H2O、TbC15H8O7Cl2.6H2O。同时采用噻唑蓝（MTT）比色法测定了配体及配合物对HepG2肝癌细胞株的抗肿瘤活性,实验结果表明,配合物对HepG2肝癌细胞的抗肿瘤活性强于配体。
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| 关 键 词： | 槲皮素 稀土金属 配合物 噻唑蓝比色法 抗肿瘤活性 |
Synthesis ,Characterization and Anti-Tumor Activity of Rare Earth-Quercetin Complexes |
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| DING Ye-Chun,XIAHOU Guo-Lun,FAN Xiao-Na,WANG En-Jun,LIU Xia.Synthesis ,Characterization and Anti-Tumor Activity of Rare Earth-Quercetin Complexes[J].Chinese Journal of Spectroscopy Laboratory,2011,28(4):1680-1683. |
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| Authors: | DING Ye-Chun XIAHOU Guo-Lun FAN Xiao-Na WANG En-Jun LIU Xia |
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| Institution: | DING Ye-Chun XIAHOU Guo-Lun FAN Xiao-Na WANG En-Jun LIU Xia(Department of Chemistry,College of Pharmacy,Gannan Medical University,Ganzhou,Jiangxi 341000,P.R.China) |
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| Abstract: | The complexes of rare earth elements Pr（Ⅲ） and Tb（Ⅲ） with quercetin were synthesized.On the basis of mass spectrometry,elemental analysis,molar conductance,IR spectra and UV spectra,the composition and structure of the complexes,PrC15H8O7Cl10·6H2O,TbC15H8O7Cl2·6H2O,were given.MTT colorimetric assay was used to detect the anti-tumor activity of the ligand and the complexes effecting on human hepatocarcinoma cell line HepG2.The result indicated that the anti-tumor activity of the complexes was stronger than that of the ligand. |
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| Keywords: | Quercetin Rare Earth Metal Complexes MTT Colorimetric Assay Anti-Tumor Activity |
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