Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae) |
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| Authors: | Ndjakou Lenta Bruno Ngouela Silvère Fekam Boyom Fabrice Tantangmo Ferdinand Feuya Tchouya Guy Raymond Tsamo Etienne Gut Jiri Rosenthal Philip Jon Donald Connolly Joseph |
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| Institution: | Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon. |
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| Abstract: | Bazouanthrone (1), a new anthrone derivative, has been isolated from the root bark of Harungana madagascariensis, together with known compounds, feruginin A (2), harunganin (3), harunganol A (4), harunganol B (5), friedelan-3-one (6) and betulinic acid (7). The structure of the compound (1) was assigned as 3,5,8,9-tetrahydroxy-2,4,4-tri-(3,3-dimethylallyl)-6-methyl-1-(4H)-anthracenone, by means of spectroscopic analysis. The anti-plasmodial activity of the isolated compounds was evaluated in culture against W2 strain of Plasmodium falciparum. All the compounds were found to be active against the Plasmodium parasites with bazouanthrone (1) showing particular potency (IC50=1.80 microM). |
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