| Abstract: | Abstract Seven new solid complexes of 5-fluorouracil-1-propionic acid with rare earth metals have been synthesized. Elemental analyses, molar conductance, TG-DTA, IR, UV-Vis, fluorescence, XPS and 1H NMR spectra have been used to characterize these complexes. The general formula of the complexes is RE(FPA)3. nH2O where RE = Y(III), La(III), Pr(III), Sm(III), Eu(III), Dy(III), Er(III); n=3 or 5. Prooxidative and antitumor activity of these complexes was tested. The results showed that these complexes augment free radical generation; especially the Pr3+ complex which obviously increased the O2 ? and OH? radicals. It was also found that La3+ and Y3+ complexes possess antitumor effects on human colon bladder HCT-B and human leukemia HL-60 cells in vitro. |
