Synthesis,characterization, semi-empirical study,and biological activities of organotin(IV) complexes with cyclohexylcarbamodithioic acid as biological active ligand

Cyclohexylcarbamodithioic acid has been synthesized by the reaction of cyclohexylamine with carbon disulfide at room temperature. Its complexes have been synthesized by the reaction of cyclohexylcarbamodithioic acid with organotin(IV) chlorides in 1?:?1/1?:?2 molar ratio. The ligand and complexes have been characterized by elemental analysis, infrared (IR), and multinuclear (¹H, ¹³C, and ¹¹⁹Sn) NMR spectroscopy. Elemental data show good agreement between calculated and found values of carbon, hydrogen, nitrogen, and sulfur. IR data show that the ligand is bidentate and complexes exhibit a five-coordinate geometry in the solid state, which is also confirmed by semi-empirical studies. NMR data show that the complexes exhibit tetrahedral geometry in solution state. The ligand and its complexes were screened for their in vitro mutagenic, antimicrobial, MIC, antioxidant activities, and cytotoxicity. Biological screening data demonstrate that complexes show significant activity against various bacterial and fungal strains and are good antioxidants. The cytotoxicity data show positive lethality for complexes as compared to ligand and can play a very significant role in drug development.