Synthesis,characterization, and antitumor activities of two copper(II) complexes with pyrazole derivatives |
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Abstract: | Two mononuclear copper(II) complexes with pyrazole derivatives, 1,1′-(anthracen-9-ylmethylene)bis(1H-pyrazole) (L1 ) and 9-(4-(di(1H-pyrazol-1-yl)methyl)phenyl)-9H-carbazole (L2 ), of formulae CuL1(CH3CN)2](ClO4)2 (1) and CuL2(CH3CN)2](ClO4)2 (2) were prepared. Both complexes were confirmed by IR, MS, 1H NMR, and elemental analyses. Complex 1 was also characterized by X-ray crystallography, confirming that copper(II) is coordinated by four nitrogen atoms from two L1 and two oxygen atoms from two perchlorates. Furthermore, all ligands and complexes were tested in vitro for their antitumor activities using mouse melanoma cell line B16-F10, HepG2 human hepatoma cell line, and A549 human lung adenocarcinoma cell line. Both complexes displayed potent cytotoxicity and are promising substrates for further investigations. |
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Keywords: | Pyrazole derivative Copper(II) complex Antitumor activity |
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