Synthesis,characterization, and cytotoxicity of platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine

Eight new platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine ligands, Pd(en)(Tsile)]·H₂O (1), Pd(bipy)(Tsile)] (2), Pd(bipy)(Tsthr)]·0.5H₂O (3), Pd(phen)(Tsile)]·0.5H₂O (4), Pd(phen)(Tsthr)]·H₂O (5), Pd(bqu)(Tsthr)]·1.5H₂O (6), Pt(en)(Tsser)] (7), and Pt(en)(Tsphe)]·H₂O (8), have been synthesized and characterized by elemental analyses, ¹H NMR and mass spectrometry. The crystal structure of 7 has been determined by X-ray diffraction. Cytotoxicities were tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and sulforhodamine B assays. The complexes exert cytotoxicity against HL-60, Bel-7402, BGC-823, and KB cell lines with 4 having the best cytotoxicity against HL-60, Bel-7402, and BGC-823 cell lines; the compounds are less cytotoxic than cisplatin.