Cytotoxic activity of iron(III), cobalt(III), nickel(II), zinc(II), and cadmium(II) complexes of 2-acetylpyrazine thiosemicarbazone: crystal structure of the cobalt(III) complex |
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| Abstract: | Transition metal complexes Fe(HL)2]Cl3 ? 1.5H2O (1), Co(L)2] ? ClO4 ? H2O (2), Ni(HL)2(ClO4)2 ? 2H2O (3), Zn(HL)L ? BF4 ? 2H2O (4), and Cd(HL)2(ClO4)2 ? 2H2O (5), where HL = C7H9N5S, 2-acetylpyrazine thiosemicarbazone, have been synthesized. Complex 2 was characterized by elemental analysis, infrared spectra, mass spectra, and single-crystal X-ray diffraction. Preliminary in vitro screening showed that 1, 4, and 5 exhibit higher antitumor activity than 2 and 3 against K562 leucocythemia cancer cell line. |
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| Keywords: | 2-Acetylpyrazine Thiosemicarbazone Metal complexes Crystal structure Cytotoxic activity |
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