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The reaction of hexamethyl phosphoric triamide (HMPT) with phosphoryl chloride : A reexamination. Application to a novel preparation of BOP reagent for peptide coupling
Authors:Jean-Robert Dormoy  Bertrand Castro
Institution:Laboratoire de Chimie Organique II, Université de Nancy I Case Officielle 140, 54037 Nancy France
Abstract:The reaction of hexamethyl phosphoric triamide with phosphoryl chloride at R.T. gave actually a chlorophosphonium salt. This reaction is illustrated in a novel preparation of BOP reagent for peptide coupling in good conditions.
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