A novel water-soluble heptaplatin analogue with improved antitumor activity and reduced toxicity |
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| Authors: | Liu Weiping Chen Xizhu Ye Qingsong Xu Yongping Xie Chengying Xie Mingjin Chang Qiaowen Lou Liguang |
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| Institution: | State Key Lab of Advanced Technologies for PGMs, Kunming Institute of Precious Metals, Kunming 650106, PR China. |
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| Abstract: | A novel water-soluble heptaplatin analogue, cis-(4R,5R)-4,5-bis-(aminomethyl)-2-isopropyl-1,3-dioxolane](3-hydroxy-1,1-cyclobutanedicarboxylato)platinum(II), has been synthesized and biologically evaluated. The complex shows more activity and less toxicity than its parent drug heptaplatin, exhibiting the great potential for further development. |
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