Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1 |
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| Authors: | Newsome Jeffery J Colucci Marie A Hassani Mary Beall Howard D Moody Christopher J |
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| Institution: | Department of Chemistry, University of Exeter, Stocker Road, Exeter, UK. |
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| Abstract: | A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1. |
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