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| PEO-PPO-PEO在生物医用材料方面的研究进展 | |
| 引用本文： | 张琰,邵芳可,吴唯,杨武利,府寿宽.PEO-PPO-PEO在生物医用材料方面的研究进展[J].高分子通报,2007(10):34-40. |
| 作者姓名： | 张琰 邵芳可 吴唯 杨武利 府寿宽 |
| 作者单位： | 1. 复旦大学聚合物分子工程教育部重点实验室,上海,200433;华东理工大学材料科学与工程学院,上海,201512 2. 华东理工大学材料科学与工程学院,上海,201512 3. 复旦大学聚合物分子工程教育部重点实验室,上海,200433 |
| 基金项目： | 复旦大学聚合物分子工程教育部重点实验室开放基金，华东理工大学校内基金(编号:JYM000011-4) |
| 摘 要： | 聚氧乙烯-聚氧丙烯-聚氧乙烯三嵌段共聚物因其具有良好的生物相容性和蛋白抗性,近年来在生物医用材料中的应用越来越广泛.聚氧乙烯-聚氧丙烯-聚氧乙烯水溶液具有温度敏感的胶束化和热可逆凝胶化特点,被认为是一种具有许多优点的药物传输载体,药物与胶束的核心结合增加了药物的溶解性、代谢稳定性和体内循环时间.本文对聚氧乙烯-聚氧丙烯-聚氧乙烯在生物医用方面的研究进展进行了综述,并重点介绍了其在药物传输载体,组织工程等方面的研究进展. |
| 关 键 词： | 聚氧乙烯-聚氧丙烯-聚氧乙烯 生物医用材料 药物载体 组织工程 |
PEO-PPO-PEO as Novel Functional Molecules for Biomedical Material |
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| ZHANG Yan,SHAO Fang-ke,WU Wei,YANG Wu-li,FU Shou-kuan.PEO-PPO-PEO as Novel Functional Molecules for Biomedical Material[J].Polymer Bulletin,2007(10):34-40. | |
| Authors: | ZHANG Yan SHAO Fang-ke WU Wei YANG Wu-li FU Shou-kuan |
| Institution: | 1. The Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Shanghai 200433, China ; 2. College of MaterialsScaienee and Engineering, East China University of Scienee and Technology i Shanghai 201512, China |
| Abstract: | Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)triblock copolymers have been investigated widely due to their excellent biological compatibility and protein-resistant properties in applications as biomedical materials.Temperature-dependent micellization and thermo-reversible gelation are two of the most characteristic properties of aqueous PEO-PPO-PEO block copolymer solutions.PEO-PPO-PEO is found to be a drug delivery system with multiple effects.The incorporation of drug into the core of the micelles formed by PEO-PPO-PEO results in increased solubility,metabolic stability and circulation time for the drug.This Paper described the use of such copolymers for drug delivery system and tissue engineering in some detail. |
| Keywords: | PEO-PPO-PEO Biomedical materials Drug delivery system Tissue engineering |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |