| Synthesis of Certain 3-Aminopyrazolo[5,4-b]pyridine and 3,4-Substituted Pyrido[2′,3′：3,4]pyrazolo[5,1-c][1,2,4]triazine Derivatives |
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| 作者姓名： | EL-LOUH Ali Khader Khalil ABUNADA Nada Mohamed EL-SHOUBAKI Mohamed |
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| 作者单位： | [1]Chemistry Department, Faculty of Science, Al-Azhar University-Gaza, Gaza 76888, Palestine [2]Chemistry Department, Faculty of Applied Sciences, Al-Aqsa University, Gaza Palestine 4051, Israel |
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| 摘 要： | 2-Thioxo-1,2-dihydropyridine derivatives 2a, 2b were reacted with methyl iodide to give 2-methylthiopyridines 3a, 3b, which were reacted with hydrazine hydrate to produce 3-aminopyrazolo5,4-b]pyridines 4a, 4b. Compounds 4a, 4b were diazotized to afford the corresponding diazonium salts 5a, 5b, which were reacted with some active methylene compounds 6a-6h to give the corresponding pyrido2′,3′ ： 3,4]pyrazole5,1-c]1,2,4]triazines 7-14.
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| 关 键 词： | 吡唑啉酮[3 4-b]吡啶 乙酸吡啶汞[2′ 3′ ： 3 4]吡唑 [ 1 2 4]三嗪 化学结构 |
| 收稿时间： | 2006-11-16 |
| 修稿时间： | 2007-05-23 |
Synthesis of Certain 3‐Aminopyrazolo[5,4‐b]pyridine and 3,4‐Substituted Pyrido[2′,3′ :3,4]pyrazolo[5,1‐c][1,2,4]triazine Derivatives |
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| EL-LOUH, Ali Khader Khalil ABUNADA, Nada Mohamed EL-SHOUBAKI, Mohamed.Synthesis of Certain 3‐Aminopyrazolo[5,4‐b]pyridine and 3,4‐Substituted Pyrido[2′,3′ :3,4]pyrazolo[5,1‐c][1,2,4]triazine Derivatives[J].Chinese Journal of Chemistry,2007,25(12):1887-1891. |
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| Authors: | EL-LOUH Ali Khader Khalil ABUNADA Nada Mohamed EL-SHOUBAKI Mohamed |
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| Institution: | Chemistry Department, Faculty of Science, Al‐Azhar University‐Gaza, Gaza 76888, Palestine |
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| Abstract: | 2‐Thioxo‐1,2‐dihydropyridine derivatives 2a , 2b were reacted with methyl iodide to give 2‐methylthiopyridines 3a , 3b , which were reacted with hydrazine hydrate to produce 3‐aminopyrazolo5,4‐b]pyridines 4a , 4b . Compounds 4a , 4b were diazotized to afford the corresponding diazonium salts 5a , 5b , which were reacted with some active methylene compounds 6a – 6h to give the corresponding pyrido2′,3′:3,4]pyrazole5,1‐c]1,2,4]triazines 7 – 14 . |
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| Keywords: | pyrazolo[3 4‐b]pyridine pyrido[2′ 3′:3 4]pyrazole[5 1‐c][1 2 4]triazine 2‐arylmethylidene‐2‐cyano‐thioacetamine 2‐thioxopyridine |
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