An effective enantioselective approach to the securinega alkaloids: total synthesis of (-)-norsecurinine |
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| Authors: | Alibés Ramón Bayón Pau de March Pedro Figueredo Marta Font Josep García-García Elena González-Gálvez David |
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| Institution: | Universitat Autonoma de Barcelona, Departament de Química, Bellaterra, Spain. |
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| Abstract: | reaction: see text] A highly versatile approach to the enantioselective synthesis of securinega alkaloids is presented. Crucial steps are a palladium-catalyzed enantioselective imide alkylation, a vinylogous Mannich reaction, and a ring-closing metathesis process. Through this strategy, the synthesis of (-)-norsecurinine has been accomplished in nine steps and 11% overall yield. |
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