1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome,SBE‐β‐CD and β‐CD |
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| Authors: | Lucas Martins Monica Arrais Alexandre de Souza Anita Marsaioli |
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| Affiliation: | 1. University of Campinas, Chemistry Institute, , Campinas, Brazil;2. Federal University of Piauí, Post‐Graduate Program in Pharmaceutics Sciences, , Teresina, Brazil |
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| Abstract: | Binary and ternary systems composed of dapsone, sulfobutylether‐β‐cyclodextrin (SBE‐β‐CD), β‐CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β‐CD (Ka 1396 l mol?1), Dap/SBE‐β‐CD (Ka 246 l mol?1), Dap/EPC (Ka 84 l mol?1) and the ternary complex Dap/β‐CD/EPC (Ka 18 l mol?1) in which dapsone is more soluble. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | NMR dapsone EPC liposome SBE‐β ‐CD β ‐CD |
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