| Effect of bovine serum albumin on the micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers in aqueous solutions by fluorescence spectroscopy |
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| 引用本文： | GUO Chen,WANG Jing,LIANG Xiangfeng,ZHENG Lili & LIU Huizhou Laboratory of Separation Science and Engineering,State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Graduate University of Chinese Academy of Sciences,Beijing 100080,China. Effect of bovine serum albumin on the micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers in aqueous solutions by fluorescence spectroscopy[J]. 中国科学B辑(英文版), 2006, 49(6): 541-549. DOI: 10.1007/s11426-006-2028-3 |
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| 作者姓名： | GUO Chen WANG Jing LIANG Xiangfeng ZHENG Lili & LIU Huizhou Laboratory of Separation Science and Engineering State Key Laboratory of Biochemical Engineering Institute of Process Engineering Graduate University of Chinese Academy of Sciences Beijing 100080 China |
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| 作者单位： | GUO Chen，WANG Jing，LIANG Xiangfeng，ZHENG Lili & LIU Huizhou Laboratory of Separation Science and Engineering，State Key Laboratory of Biochemical Engineering，Institute of Process Engineering，Graduate University of Chinese Academy of Sciences，Beijing 100080，China |
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| 基金项目： | 国家自然科学基金;教育部留学回国人员科研启动基金 |
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| 摘 要： | Effect of bovine serum albumin (BSA) on the temperature-dependent association behavior of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers was investigated using pyrene fluorescence spectroscopy. The critical micellization temperature (CMT) of pluronics in aqueous solution was increased by the addition of BSA. A closed association model was used to obtain the standard free energies (△G0), enthalpies (△H 0), and entropies (△S 0) of micellization. The standard enthalpy and entropy of micellization for pluronic polymers in water were decreased with an increase of the BSA content. The more PPO component in the pluronic polymer, the higher the changed values of micellization enthalpy and entropy. The hydrophobic part of the pluronics, PPO, was responsible for the interaction between pluronics and BSA. Hydrophobic interaction between PPO and BSA was correlated to the alternation of the PPO-PPO interaction by the addition of BSA, which would shift the CMT toward higher temperature and alter the thermodynamic parameters of micellization for pluronics in aqueous solutions.
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| 收稿时间： | 2005-10-25 |
| 修稿时间： | 2006-02-06 |
Effect of bovine serum albumin on the micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers in aqueous solutions by fluorescence spectroscopy |
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| GUO Chen,WANG Jing,LIANG Xiangfeng,ZHENG Lili,LIU Huizhou. Effect of bovine serum albumin on the micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers in aqueous solutions by fluorescence spectroscopy[J]. Science in China(Chemistry), 2006, 49(6): 541-549. DOI: 10.1007/s11426-006-2028-3 |
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| Authors: | GUO Chen WANG Jing LIANG Xiangfeng ZHENG Lili LIU Huizhou |
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| Affiliation: | Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Graduate University of Chinese Academy of Sciences, Beijing 100080, China |
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| Abstract: | Effect of bovine serum albumin (BSA) on the temperature-dependent association behavior of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers was investigated using pyrene fluorescence spectroscopy. The critical micellization temperature (CMT) of pluronics in aqueous solution was increased by the addition of BSA. A closed association model was used to obtain the standard free energies (ΔG 0), enthalpies (ΔH 0), and entropies (ΔS 0) of micellization. The standard enthalpy and entropy of micellization for pluronic polymers in water were decreased with an increase of the BSA content. The more PPO component in the pluronic polymer, the higher the changed values of micellization enthalpy and entropy. The hydrophobic part of the pluronics, PPO, was responsible for the interaction between pluronics and BSA. Hydrophobic interaction between PPO and BSA was correlated to the alternation of the PPO-PPO interaction by the addition of BSA, which would shift the CMT toward higher temperature and alter the thermodynamic parameters of micellization for pluronics in aqueous solutions. |
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| Keywords: | block copolymer bovine serum albumin micelle fluorescence spectroscopy |
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