| 中红外无创血糖研究进展并论角质层影响 |
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| 引用本文： | 陈星旦,王动民,卢启鹏,丁海泉.中红外无创血糖研究进展并论角质层影响[J].光学学报,2011(9):58-63. |
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| 作者姓名： | 陈星旦 王动民 卢启鹏 丁海泉 |
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| 作者单位： | 暨南大学光电工程系光电信息与传感技术广东普通高校重点实验室;中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室; |
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| 基金项目： | 国家自然科学基金(61078038,60938002,60878052); 中国科学院知识创新工程领域前沿(Y00232Q100); 应用光学国家重点实验室开放基金(O9Q13FQ090)资助课题 |
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| 摘 要： | 在介绍中红外无创血糖研究进展的基础上,实验探讨了组织液渗透到手指皮肤表面时,角质层对血糖测量的影响.加入角质层干扰信息前,用偏最小二乘法(PLSR)建立了模拟组织液中葡萄糖定标模型,其内部交叉验证均方差(RMSECV)为9.6 mg/dL;加入三个志愿者手指皮肤吸收的干扰信息后,所得三个模型的RMSECV分别为17.4...
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| 关 键 词： | 中红外光谱 衰减全反射 无创血糖检测 糖尿病 |
Progress of MIR Non-Invasive Blood Glucose Determination and Effect of Stratum Corneum |
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| Chen Xingdan, Wang Dongmin Lu Qipeng Ding Haiquan.Progress of MIR Non-Invasive Blood Glucose Determination and Effect of Stratum Corneum[J].Acta Optica Sinica,2011(9):58-63. |
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| Authors: | Chen Xingdan Wang Dongmin Lu Qipeng Ding Haiquan |
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| Institution: | Chen Xingdan1,2 Wang Dongmin1 Lu Qipeng2 Ding Haiquan2(1Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou,Guangdong 510632,China 2State Key Laboratory of Applied Optics,Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,Changchun,Jilin 130018,China) |
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| Abstract: | The progress of non-invasive blood glucose determination based on mid-infrared spectroscopy is introduced firstly.After this,the effect of stratum corneum(SC) on blood glucose determination is studied by experiment while interstitial fluid(ISF) is collected on the skin surface.Using the spectra of simulated ISF,partial least square regression(PLSR) calibration model of glucose determination is estabished,and the value of root mean squares error of cross validation(RMSECV) is 9.6 mg/dL.While including the in... |
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| Keywords: | mid-infrared spectroscopy attenuated total reflection non-invasive blood glucose determination diabetics |
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