超声心动图诊断胎儿先心病及危险因素分析

本研究探讨超声心动图在胎儿先心病诊断中的价值以及影响先心病发病的危险因素。采用回顾性研究方法,选取孕产妇18987例,均进行系统的彩色多普勒超声检查,同时问卷调查胎儿先心病家庭65例(病例组)及130例正常胎儿家庭(对照组)的病史等情况。结果显示,先心病发病率为0.43%,疾病类型中:以单纯性室间隔缺损、心内膜垫缺损和右心室双出口为主;Logistic回归分析结果显示:产妇年龄、孕期有致畸物接触史、产妇糖尿病、产妇结缔病、不良妊娠史、染色体异常、胎儿早期NT值、先心病家族史是先心病发生的影响因素(P<0.05)。从上述结果可知,超声心动图在胎儿先心病诊断中有较好的价值,先心病发病受产妇年龄、致畸物接触史等因素的影响。

Value and Risk Factors of Echocardiography in the Diagnosis of Fetal Congenital Heart Disease

This study explored the value of echocardiography in the diagnosis of fetal congenital heart disease and the risk factors affecting the onset of congenital heart disease.A retrospective study was conducted,18987 pregnant women underwent prenatal examination were selected,and 65 families with fetal congenital heart disease(case group)and 130 families with normal fetus(control group)were investigated by questionnaire.The incidence rate of congenital heart disease was 0.43%,the disease types were simple ventricular septal defect,endocardial cushion defect and double outlet of right ventricle;Logistic regression analysis showed that maternal age,history of teratogen exposure during pregnancy,maternal diabetes mellitus,maternal connective disease,adverse pregnancy history,chromosomal abnormalities,early fetal NT value and family history of congenital heart disease were the influencing factors of congenital heart disease(P<0.05).It is concluded that echocardiography has good value in the diagnosis of fetal congenital heart disease,and the incidence of congenital heart disease is affected by maternal age,teratogenic exposure history and other factors.