| 微量热法研究药物对肿瘤细胞的诱导分化作用 |
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| 引用本文： | 谭安民,徐波,屈松生. 微量热法研究药物对肿瘤细胞的诱导分化作用[J]. 物理化学学报, 1996, 12(9): 849-851. DOI: 10.3866/PKU.WHXB19960915 |
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| 作者姓名： | 谭安民 徐波 屈松生 |
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| 作者单位： | Department of Chemsitry,Wuhan University,Wuhan 430072,National Key Laboratory of Natural and Biomimetric Drugs,Beijing 100083 |
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| 基金项目： | 国家自然科学基金，天然药物及仿生药物国家重点实验室资助 |
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| 摘 要： |
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| 关 键 词： | 微量热法 HL-60细胞 诱导分化 |
| 收稿时间： | 1996-01-29 |
| 修稿时间： | 1996-04-25 |
Microcalorimetric Study on Induced Differentiation of Tumour Cells by Drug |
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| Tan An-Min,Xu Bo,Qu Song-Sheng. Microcalorimetric Study on Induced Differentiation of Tumour Cells by Drug[J]. Acta Physico-Chimica Sinica, 1996, 12(9): 849-851. DOI: 10.3866/PKU.WHXB19960915 |
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| Authors: | Tan An-Min Xu Bo Qu Song-Sheng |
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| Affiliation: | Department of Chemsitry,Wuhan University,Wuhan 430072|National Key Laboratory of Natural and Biomimetric Drugs,Beijing 100083 |
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| Abstract: | Sp-Octyl-(8-Chloroadenosine)-3',5'-Cyclophosphate (OCC), a newlysynthesized cAMP analog, strongly induces growth inhibition and differentiation in human promyelocytic leukemia HL-60 cells. The effect of OCC is dose-time dependent. By using the LKB2277 Bioactivity Monitor, we determined the heat production rate of HL-60 cells treated by OCC at different concentrations. It was found that the heat production rate of HL-60 cell treated by OCC gradually decreased to that of normal human neutrophiles. |
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| Keywords: | Microcalorimetry OCC HL-60 cells Induced differentiation |
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