Congener-specific method for the determination of ortho and non-ortho polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in foods by carbon-column fractionation and gas chromatography-isotope dilution mass spectrometry |
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Authors: | F Krokos C S Creaser C Wright J R Startin |
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Institution: | (1) CSL Food Science Laboratory, Norwich Research Park, Colney, Norwich NR4 7UQ, UK, GB;(2) Department of Chemistry & Physics, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK, GB |
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Abstract: | The chromatographic behavior of ortho and non-ortho polychlorinated biphenyls (PCBs) on supported carbon columns has been investigated and the structure-affinity relationship
of activated carbon towards PCB molecules established. Optimisation of the parameters controlling the elution of PCB congeners
through the carbon column led to the development of a solvent scheme for the efficient separation of (i) ortho substituted PCBs, (ii) non-ortho substituted PCBs and (iii) polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in three separate fractions. A method for the extraction, clean-up,
fractionation and determination of ortho and non-ortho substituted PCBs by GC-isotope dilution MS was developed and validated by analysis of a certified reference material. Possible
losses of PCBs during freeze-drying and interferences of aliphatic hydrocarbons during mass spectrometric determination of
ortho substituted PCBs are also discussed.
Received: 23 June 1995/Revised: 9 May 1996/Accepted: 25 May 1996 |
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