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Asymmetric Total Synthesis of (+)‐Neooxazolomycin Using a Chirality‐Transfer Strategy
Authors:Jae Hyun Kim  Illan Kim  Yeonghun Song  Min Jung Kim  Sanghee Kim
Abstract:
The total synthesis of (+)‐neooxazolomycin was achieved from the amino‐acid d ‐serine. The efficiency of this approach is derived from the use of principles of memory of chirality and dynamic kinetic resolution in the intramolecular aldol reaction of a serine derivative to build the densely functionalized lactam framework and to install three contiguous stereocenters. The key intermediate was readily elaborated to the target natural product.
Keywords:Alkaloide  Asymmetrische Synthese  Diastereoselektivitä  t  Naturstoffe  Totalsynthese
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