Synthesis of 2-(3-amino-2-oxoindolin-3-yl)-3-hydroxynaphthalene-1,4-dione derivatives via a one-pot,three-component reaction under catalyst-free conditions |
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Institution: | College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, PR China |
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Abstract: | A concise, facile and straightforward synthetic method has been described for the synthesis of 2-(3-amino-2-oxoindolin-3-yl)-3-hydroxynaphthalene-1,4-dione derivatives by a one-pot, three-component reaction of isatins, 2-hydroxy-1,4-naphthoquinone and ammonium acetate under catalyst-free conditions in ethanol. This protocol becomes highly efficient due to its mild reaction conditions, operational simplicity, and overall good to excellent yields (80–99%). |
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Keywords: | 2-(3-Amino-2-oxoindolin-3-yl)-3-hydroxynaphthalene-1 4-dione derivatives Ammonium acetate Catalyst-free 2-Hydroxy-1 4-naphthoquinone One-pot |
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