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Sila-Analoga des Chlorphenoxamins und des Clofenetamins |
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| Authors: | Reinhold Tacke Ulrich Wannagat |
| Institution: | (1) Institut für Anorganische Chemie der Technischen Universität Braunschweig, Pockelsstraße 4, D-3300 Braunschweig, Bundesrepublik Deutschland |
| Abstract: | Sila-analoguesA 2 andB 2 of two drugs from the benzhydryl ether class, chlorphenoxamine and clofenetamine, were synthesized for the first time by the steps shown in scheme 1. They and their precursors I–VI were characterized by their physical (Table 1) and chemical properties and their structures confirmed by n.m.r., mass and infrared spectrocopy (Tables 2–5). Their physiological effects were investigated and compared with those of the carbon analogues (Chapter 5). 1. Mitt.:R. Tacke undU. Wannagat, Mh. Chem.106, 1005 (1975). Mit Auszügen aus der DissertationR. Tacke, Techn. Univ. Braunschweig 1974. |
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