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Enantioselective organocatalytic aldol reaction of unactivated ketones with isatins |
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| Authors: | Suresh AlluNagaraju Molleti Ramachandrarao PanemVinod K. Singh |
| Affiliation: | a Department of Chemistry, Indian Institute of Technology, Kanpur, UP 208 016, India b Department of Chemistry, Indian Institute of Science Education and Research, ITI (Gas Rahat) Building, Govindpura, Bhopal, MP 462 023, India |
| Abstract: | Enantioselective organocatalytic direct aldol reaction of unactivated ketones with various isatin derivatives was developed using cinchonine based urea ligand employing a noncovalent catalysis mechanism. Using this protocol we can access functionalized 3-alkyl-3-hydroxyindolin-2-ones in high yields with good to excellent enantioselectivities. |
| Keywords: | Organocatalysis Thiourea Isatin Enamine mechanism 3-Alkyl-3-hydroxyindolin-2-ones |
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