Chiral separation with novel (S)-biotin-bonded silica gel for liquid chromatography |
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| Authors: | Kurata Kaori Sakamoto Satoru Dobashi Akira |
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| Affiliation: | Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. kurata@ps.toyaku.ac.jp |
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| Abstract: | ![]()
Liquid chromatographic separation of enantiomers was accomplished using a chiral stationary phase (CSP) derived from (S)-biotin on silica gel. In both nonaqueous and aqueous media, this CSP (1) permitted separation of racemic amino acid derivatives based on hydrogen bonding with a urea moiety of the biotin moiety. |
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| Keywords: | Corresponding author. Fax: +81 426 70 7067. |
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