De novo synthesis of sugar-aza-crown ethers via a domino Staudinger aza-Wittig reaction |
| |
| Authors: | Ménand Mickaël Blais Jean-Claude Valéry Jean-Marc Xie Juan |
| |
| Affiliation: | Synthèse, Structure et Fonction des Molécules Bioactives, CNRS UMR 7613, Université Pierre et Marie Curie, 4 Place Jussieu, F-75005 Paris, France. |
| |
| Abstract: | ![]()
A short and highly efficient route to sugar-aza-crown (SAC) ethers has been developed. The key step of the transformation is a one-pot cyclodimerization of C-glycosyl azido aldehydes via a domino Staudinger aza-Wittig reaction. This process allows the preparation of various orthogonally protected SAC ethers, from both alpha- and beta-C-glycosyl azido aldehydes. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
