TmDOTA-: a sensitive probe for MR thermometry in vivo. |
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| Authors: | C S Zuo A Mahmood A D Sherry |
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| Affiliation: | Department of Radiology, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, Massachusetts 02215, USA. czuo@caregroup.harvard.edu |
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| Abstract: | The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo. |
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