Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors |
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| Authors: | Haibo Wang Senling Tang Guoqing Zhang Yang Pan Wei Jiao Huawu Shao |
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| Affiliation: | 1.Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;2.University of Chinese Academy of Sciences, Beijing 100049, China;3.Zhejiang Hongyuan Pharmaceutical Co., Ltd., Linhai 317016, China;4.School of Pharmacy, North Sichuan Medical College, Nanchong 637100, China |
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| Abstract: | ![]()
A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor. Enzymatic kinetic assays indicated that compound 6e may be classified as an uncompetitive inhibitor. The study of structure-activity relationships of those iminosugars provided a starting point for the discovery of new α-glucosidase inhibitors. |
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| Keywords: | iminosugars, C-glycosides, α -glucosidase, inhibitors |
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