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| TRANSFER MECHANISM OF QUININE DRUG ACROSS THE OIL/WATER (O/W) INTERFACE | |
| 引用本文： | 肖俊,聂利华,姚守拙. TRANSFER MECHANISM OF QUININE DRUG ACROSS THE OIL/WATER (O/W) INTERFACE[J]. 中国科学B辑(英文版), 1991, 0(1) |
| 作者姓名： | 肖俊 聂利华 姚守拙 |
| 作者单位： | New Material Research Institute，Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410012，PRC，New Material Research Institute，Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410012，PRC，New Material Research Institute，Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410012，PRC |
| 基金项目： | Project supported by the National Natural Science Foundation of China. |
| 摘 要： | The transfer phenomena of quinine drug at the aqueous 1,2- dichloroethane (DCE)interface have been studied by the current- scanning polarography. The relationships be-tween the wave height and pH of aqueous phase, concentration of quinine as well as therate of water drop are discussed. The effect of supporting electrolyte, buffer solution andthe nature of organic solvent on the polarographic wave is studied. The transfer char-acteristics of quinine in aqueous phase and in organic phase are compared, The mono- pro-tonated and diprotonated quinines can both transfer at the interface so as to produce twopolarographic waves. The transfer process of quinine at the interface is simultaneouslycontrolled by diffusion and reestablishment of the disturbed protonated equilibrium ofquinine. A further investigation is made by chronopotentiometry. On the basis of thetheoretical analysis, the formulae of the limiting current are derived and discussed. Thetheoretical results are in agreement with the experimental ones. |
TRANSFER MECHANISM OF QUININE DRUG ACROSS THE OIL/WATER (O/W) INTERFACE |
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| XIAO JUN,ME LI-HUA,YAO SHOU-ZHUO New Material Research Institute. TRANSFER MECHANISM OF QUININE DRUG ACROSS THE OIL/WATER (O/W) INTERFACE[J]. Science in China(Chemistry), 1991, 0(1) | |
| Authors: | XIAO JUN ME LI-HUA YAO SHOU-ZHUO New Material Research Institute |
| Affiliation: | XIAO JUN,ME LI-HUA,YAO SHOU-ZHUO New Material Research Institute,Department of Chemistry and Chemical Engineering,Hunan University,Changsha 410012,PRC |
| Abstract: | The transfer phenomena of quinine drug at the aqueous 1,2- dichloroethane (DCE)interface have been studied by the current- scanning polarography. The relationships be-tween the wave height and pH of aqueous phase, concentration of quinine as well as therate of water drop are discussed. The effect of supporting electrolyte, buffer solution andthe nature of organic solvent on the polarographic wave is studied. The transfer char-acteristics of quinine in aqueous phase and in organic phase are compared, The mono- pro-tonated and diprotonated quinines can both transfer at the interface so as to produce twopolarographic waves. The transfer process of quinine at the interface is simultaneouslycontrolled by diffusion and reestablishment of the disturbed protonated equilibrium ofquinine. A further investigation is made by chronopotentiometry. On the basis of thetheoretical analysis, the formulae of the limiting current are derived and discussed. Thetheoretical results are in agreement with the experimental ones. The transfer mechanismof quinine is put forward. |
| Keywords: | oil/water (O/W) interface ITIES kinetic current quinine drug current-scanning polarography |
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