Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis |
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| Authors: | Wagenaar Melissa M Gibson Donna M Clardy Jon |
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| Affiliation: | Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, USA. |
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| Abstract: | ![]()
[structure: see text] Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH2Cl2 extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Akanthomycin was characterized using X-ray crystallography and NMR. |
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