Synthesis and In Vitro Anticancer Activity of Novel 1,3,4‐Oxadiazole‐Linked 1,2,3‐Triazole/Isoxazole Hybrids |
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| Authors: | Gowravaram Sabitha B V Subba Reddy J S Yadav Nishant Jain B Jagan Mohan Reddy |
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| Institution: | 1. Natural Products Chemistry Division, CSIR Indian Institute of Chemical Technology, Hyderabad, 500007 India;2. Academy of Scientific and Innovative Research (AcSIR), 2 Rafi Marg, New Delhi, 110 001 IndiaE‐mail:;3. Academy of Scientific and Innovative Research (AcSIR), 2 Rafi Marg, New Delhi, 110 001 India;4. Center for Semiochemicals, CSIR Indian Institute of Chemical Technology, Hyderabad, 500007 IndiaE‐mail:;5. Center for Semiochemicals, CSIR Indian Institute of Chemical Technology, Hyderabad, 500007 India;6. Center for Chemical Biology, CSIR Indian Institute of Chemical Technology, Hyderabad, 500007 India;7. Department of Chemistry, Adikavi Nannaya University, Rajahmundry, 533296 India |
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| Abstract: | A series of new 1,3,4‐oxadiazole‐linked 1,2,3‐triazole/isoxazole derivatives were designed and synthesized. All the synthesized compounds were screened for in vitro anticancer activity against four human cancer cells: HeLa (cervical), MDA‐MB‐231 (breast), DU‐145 (prostate), and HEPG2 (liver). Among 17 compounds tested, 7a , 7c , and 7d showed potent activity toward four cell lines. |
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