Bacterial homologue of human blood group A transferase |
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Authors: | Yi Wen Shen Jie Zhou Guangyan Li Jianjun Wang Peng George |
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Institution: | Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA. |
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Abstract: | A bacterial version of human blood group A transferase was identified and found to be able to accept five naturally existing H-antigen core structures as good substrates, demonstrating its versatility for synthesis of blood group A antigens. Furthermore, this enzyme was applied in the engineering of bacterial cell surface polysaccharides by remodeling blood group B mimicry into blood group A mimicry. |
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