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Catalytic asymmetric synthesis of spirooxindoles by a mannich-type reaction of isothiocyanato oxindoles |
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| Authors: | Kato Shota Yoshino Tatsuhiko Shibasaki Masakatsu Kanai Motomu Matsunaga Shigeki |
| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Japan. |
| Abstract: | Easy access: a strontium/Schiff base complex as catalyst for the title reaction provided straightforward access to enantiomerically enriched spiroimidazolidine-4,3'-oxindole] compounds, as well as a spiroimidazoline-4,3'-oxindole] through a two-step conversion from the Mannich adduct. |
| Keywords: | asymmetric catalysis asymmetric synthesis Mannich reaction oxindoles salen |
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