Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family |
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| Authors: | Cichewicz Robert H Valeriote Frederick A Crews Phillip |
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| Affiliation: | Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA. |
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| Abstract: | ![]()
[structure: see text] Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development. |
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