手性磷酸酯配体的设计合成及其在不对称加氢中的应用研究新进展

合成对映体纯的药品、农用化学品及风味调料，对化学家来说是个巨大的挑战．目前采用多种不同的方法可以合成这些光学纯化合物，从工业化生产的角度来看，不对称催化反应作为获得光学纯化合物的一种手段，在众多方法中最具经济效益，同时也最具挑战性．该领域的大量出版物，

Progress in design and synthesis of Chiral phosphite Ligand and its application in asymmetric hydrogenation catalysis

In this papers, we will summarize the past decade, synthesis of phosphite ligands and their application in asymmetric hydrogenation. Were introduced design and synthesis of bidentate, monodentate, and heterocyclic P, P 'ligands, heterocyclic P, N ligands, as well as in catalytic asymmetric hydrogenation of the results obtained and briefly discussed aspects of the mechanism. For each specific reactions, we are particularly concerned about the optimization of reaction conditions.