Solid-phase synthesis of heterocycles via palladium-catalyzed annulation |
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| Authors: | Yao Wang Tai-Nang Huang |
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| Affiliation: | Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA |
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| Abstract: | Solid-phase linked o-iodoanilines (4) and o-iodophenol (9) reacted with 1,3- and 1,4-dienes in the presence of palladium acetate to generate highly substituted indolines, tetrahydroquinolines, hydrobenzofurans and hydrobenzopyrans, which provided an efficient way for making heterocyclic molecule libraries. |
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