New lignans from <Emphasis Type="Italic">Syringa reticulata</Emphasis> var. <Emphasis Type="Italic">mandshurica</Emphasis> |
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| Authors: | Qiong-ming Xu Quan Li Yan-li Liu Yu-lin Feng Shi-lin Yang Xiao-ran Li |
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| Institution: | (1) College of Pharmacy, Soochow University, Suzhou, 215123, P. R. China;(2) College of Jiangxi Traditional Chinese Medicine, Nanchang, 330004, P. R. China; |
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| Abstract: | In the search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the leaves of
Syringa reticulata Hara var. mandshurica. Their structures were elucidated as (7R,8S, 8'S)-3,4,3',4'-dimethylenedioxy-8,9-dihydroxy-8.8', 7-O-9'-lignan (mandshuricol A) and (7R,8S,8'S)-3',4'methylenedioxy-4-methoxy-3,8,9-trihydroxy-8.8', 7-O-9'-lignan (mandshuricol B), Mandshuricol A and B showed antagonistic activity on PAF in the 3H] PAF receptor binding assay with IC50 values of 4.8 × 10–5 M and 3.5 × 10–5 M, respectively. |
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