1. Department of Biotechnology, Biocatalysis and Organic Chemistry, Delft University of Technology, Julianalaan 136, 2628 BL Delft (The Netherlands), Fax: (+31)?152‐781‐415;2. Institute of Organic Chemistry I, University of Ulm, Albert‐Einstein‐Allee 11, 89081 Ulm (Germany);3. Department of Chemistry and Pharmacy, University of Erlangen–Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany);4. Department of General, Organic and Biomedical Chemistry, University of Mons‐Hainaut, Avenue du Champ de Mars, 24 7000 Mons (Belgium);5. Groningen Biomolecular Sciences and Biotechnology Institute, Electron Microscopy Group, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands)
Abstract:
The novel amphipilic conjugate of a calix[4]arene with four Gd–1,4,7,10‐ tetra(carboxymethyl)‐1,4,7,10‐tetraazacyclododecane (DOTA) chelates has potential as a magnetic resonance imaging contrast agent, both in its monomeric and in its micellar form. The system, illustrated here with its nuclear magnetic relaxation profile, shows good relaxivities, thanks to its high rigidity.
