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Energetics,Conformation, and Recognition of DNA Duplexes Modified by Methylated Analogues of [PtCl(dien)]+ |
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| Authors: | Olga Nováková Dr Jaroslav Malina Dr Jana Kašpárková Dr Anna Halámiková Dr Vladan Bernard Francesco Intini Dr Giovanni Natile Prof Dr Viktor Brabec Prof Dr |
| Institution: | 1. Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i. Kralovopolska 135, CZ‐61265 Brno (Czech Republic), Fax: (+420)?541240499;2. Laboratory of Biophysics, Department of Experimental Physics Faculty of Sciences, Palacky University, 771 46 Olomouc (Czech Republic);3. Department of Pharmaceutical Chemistry, University of Bari, 70125 Bari (Italy) |
| Abstract: | Monodentate DNA binding of PtCl(dien)]+ (dien=diethylenetriamine) complexes may considerably affect the biophysical properties of DNA and consequently downstream cellular processes as a result of a large increase in the bulkiness of the nonleaving ligand by multiple methylation (see illustration).  |
| Keywords: | DNA DNA recognition DNA structures platinum polymerization |