Characterisation of mixed lithium dodecyl sulphate/lithium perfluorooctanesulphonate pseudo‐stationary phases in MEKC |
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| Authors: | András Varga Mónika Huszár Zsófia Dobos Éva Kiss Anikó Horváth Miklós Idei |
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| Institution: | 1. Pathobiochemistry Research Group of Hungarian Academy of Sciences and Semmelweis University, Hungary;2. Laboratory of Interfaces and Nanostructures, Institute of Chemistry, Loránd E?tv?s University, Hungary |
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| Abstract: | Lipophilicity and methylene selectivity of mixed pseudo‐stationary phases (PSPs) (containing lithium dodecyl sulphate (LDS) and lithium perfluorooctanesulphonate (LiPFOS) in different molar ratios) applied in MEKC have been investigated. Micellar proportion (tprop,mic, a quantity expressing that how much time is spent by the analyte in the micellar phase related to its whole migration time), CLOGP50 value (showing the value of hydrophobicity of a molecule spending exactly 50% of its migration time in the PSP) and methylene selectivity have been determined for different LDS/LiPFOS mixed phases. Values of the above‐mentioned parameters have been determined for analytes with different chemical structures (alkylbenzene and alkylphenone homologous series, alcohols). Good linear correlation was obtained between either the micellar proportion, CLOGP50, or methylene selectivity and the phase composition for the mixed phases. Lipophilicity and methylene selectivity of the mixed LDS/LiPFOS PSPs can be calculated and can continuously be changed by mixing the two single phases (LDS and LiPFOS) in the appropriate (and calculable) portion. |
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| Keywords: | MEKC Methylene selectivity Micellar phase residence time Micellar proportion Mixed pseudo‐stationary phase |
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