K2CO3‐Promoted Cascade Michael‐Alkylation Reactions: A Facile Preparation of Diethyl trans‐2,3‐Disubstituted 1,1‐Cyclopropanedicarboxylates |
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| Authors: | Gaosheng Yang Yuanyuan Hua Yue Shen |
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| Institution: | 1. Tel.: 0086‐0553‐3869310;2. Fax: 0086‐0553‐3883517;3. Anhui Key Laboratory of Functional Molecular Solids, Institute of Organic Chemistry, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China |
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| Abstract: | A cascade Michael‐alkylation reaction of diethyl benzylidenemalonates with chloroacetophenones was realized by using K2CO3 as the promoter. With this method, a series of diethyl trans‐2,3‐disubstituted 1,1‐cyclopropane‐ dicarboxylates have been facilely synthesized in moderate yields under mild conditions. The relative configurations of two typical products were confirmed by X‐ray crystallographic analysis. |
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| Keywords: | synthesis cyclopropane potassium carbonate |
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